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Regional lung function in ankylosing spondylitis

R M Stewart, J B Ridyard, J D Pearson

    Thorax
    |August 1, 1976
    PubMed
    Summary
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    Ankylosing spondylitis patients exhibit reduced lung volumes and impaired xenon-133 distribution to lung apices, suggesting potential links to apical lung disease. This study investigated regional pulmonary function in these patients.

    Area of Science:

    • Pulmonary Medicine
    • Radiology
    • Rheumatology

    Background:

    • Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily affecting the spine.
    • Chest cage rigidity is a known complication of AS, potentially impacting respiratory mechanics.
    • Apical lung disease is observed in some AS patients, but its pathogenesis is not fully understood.

    Purpose of the Study:

    • To assess regional pulmonary function in patients with AS-related chest cage rigidity.
    • To investigate the distribution of ventilation using xenon-133 in this patient cohort.
    • To explore potential correlations between pulmonary function abnormalities and apical lung disease in AS.

    Main Methods:

    • Utilized xenon-133 (a radioactive gas) to study regional lung function.

    Related Experiment Videos

  • Compared pulmonary function parameters in nine AS patients with those of healthy subjects.
  • Analyzed lung volumes and xenon distribution patterns, particularly to lung apices.

    • Main Results:

    • Patients with AS demonstrated an overall decrease in lung volumes compared to controls.
    • The proportion of inhaled xenon-133 reaching the lung apices was significantly reduced in AS patients.
    • The distribution of injected xenon-133 throughout the lungs was found to be normal.

    Conclusions:

    • Chest cage rigidity in ankylosing spondylitis is associated with diminished lung volumes.
    • Reduced xenon-133 uptake in lung apices may indicate early or subclinical apical lung disease in AS.
    • Further research is warranted to elucidate the relationship between these pulmonary findings and apical lung pathology in AS.