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Related Experiment Videos

Aqueous hydrocortisone mouthwash solution: clinical evaluation

W P Holbrook1, T Kristmundsdóttir, T Loftsson

  • 1Faculty of Odontology and Department of Pharmacy, University of Iceland, Reykjavík.

Acta Odontologica Scandinavica
|August 4, 1998
PubMed
Summary

A new hydrocortisone mouthwash offers an easier way to treat oral mucosal conditions like aphthous ulcers and lichen planus. This aqueous solution showed significant patient improvement in a clinical study, providing a viable alternative to topical steroid creams.

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Area of Science:

  • Oral medicine
  • Dermatology
  • Pharmaceutics

Background:

  • Topical steroids in orabase present application challenges for oral mucosa, especially for extensive areas.
  • Patient adherence can be limited by the difficulty of applying traditional topical steroid formulations.

Purpose of the Study:

  • To evaluate the efficacy and acceptability of an aqueous hydrocortisone mouthwash for treating oral mucosal lesions.
  • To provide a more patient-friendly alternative for topical steroid delivery to the oral mucosa.

Main Methods:

  • An aqueous solution containing hydrocortisone (0.3% w/v) and 2-hydroxypropyl-beta-cyclodextrin (4.5% w/v) was formulated.
  • Hydroxypropylmethylcellulose (0.5% w/v) was incorporated to enhance viscosity and stabilize the hydrocortisone-cyclodextrin complex.

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  • An open clinical efficacy study involving 102 patients with conditions such as aphthous ulceration and lichen planus was conducted over 2 weeks.

    • Main Results:

    • A majority of patients reported improvement after a 2-week treatment course.
    • Significant improvement was observed in patients with aphthous ulceration (78.8%) and lichen planus (48.1%).
    • No serious adverse events were reported during the study.

    Conclusions:

    • Aqueous hydrocortisone mouthwash is a potentially effective and well-tolerated vehicle for topical steroid therapy of oral mucosal lesions.
    • This formulation offers a promising alternative for patients experiencing difficulties with traditional topical steroid applications.
    • The mouthwash demonstrated good clinical efficacy across various oral mucosal conditions.