Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Visual system maldevelopment disrupts extraocular muscle-specific myosin expression

J K Brueckner1, J D Porter

  • 1Department of Anatomy, University of Kentucky Medical Center, Lexington, Kentucky 40536-0084, USA.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|August 4, 1998
PubMed
Summary

Visual cues during a critical developmental period significantly impact extraocular muscle (EOM) phenotype, affecting myosin heavy chain (MHC) expression. This highlights the importance of early visual input for eye muscle development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessing South African medical interns' experience and confidence in managing obstetric emergencies.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2021
Same author

Lengthening extraocular muscle with autologous muscle transplants.

Strabismus·2011
Same author

Developmental adaptations in the extraocular muscles of Macaca nemestrina may reflect a predisposition to strabismus.

Strabismus·2011
Same author

Adherence to TB preventive therapy for HIV-positive patients in rural South Africa: implications for antiretroviral delivery in resource-poor settings?

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2005
Same author

Missed opportunities? Coercion or commitment: policies of prevention.

Annals of the New York Academy of Sciences·2002
Same author

An evaluation of low-cost progression markers in HIV-1 seropositive Zambians.

HIV medicine·2001

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Muscle Physiology

Background:

  • The genetic and epigenetic factors governing extraocular muscle (EOM) phenotype are not well understood.
  • Visual input is hypothesized to play a role in EOM maturation and maintenance.

Purpose of the Study:

  • To investigate the influence of visual cues on EOM maturation.
  • To assess the impact of visual deprivation paradigms on EOM phenotype, specifically myosin heavy chain (MHC) expression.

Main Methods:

  • Rats were subjected to two visual deprivation methods: dark rearing and monocular deprivation.
  • Myosin heavy chain (MHC) isoform expression and mRNA levels were analyzed in EOMs.
  • Phenotypic changes were evaluated in developing and adult EOMs.

Related Experiment Videos

Main Results:

  • Dark rearing during the critical visual period significantly reduced the proportion of EOM fibers expressing fast or slow MHCs.
  • EOM-specific myosin mRNA levels decreased significantly in dark-reared rats during the critical period.
  • Monocular deprivation had minimal effects on MHC isoform expression and no effect on EOM-specific myosin.

Conclusions:

  • There is a critical developmental period where visual activity significantly influences the EOM phenotype.
  • Visual input to the oculomotor system during development modulates EOM-specific MHC expression.
  • Dark rearing during this period alters EOM fiber type composition and myosin expression.