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Stretch in Brain Microvascular Endothelial Cells (cEND) as an In Vitro Traumatic Brain Injury Model of the Blood Brain Barrier
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Effect of mechanogated membrane ion channel blockers on experimental traumatic brain oedema

R Vaz1, A Sarmento, N Borges

  • 1Institute of Pharmacology and Therapeutics, Medical Faculty, Hospital S. João, Porto, Portugal.

Acta Neurochirurgica
|August 5, 1998
PubMed

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Cytotoxic edema is a form of cerebral edema characterized by intracellular swelling of neurons, astrocytes, and other glial cells. It develops when the mechanisms responsible for maintaining ionic gradients across the cell membrane become impaired. Under normal physiological conditions, the sodium–potassium ATPase actively transports sodium ions out of the cell and potassium ions into the cell, preserving osmotic balance and enabling electrical signaling. This pump requires a continuous supply...