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The relationship between apolipoprotein E and serum oxidation-related variables is apolipoprotein E phenotype
J D Smith1, M Miyata, S E Poulin
1Rockefeller University, New York, NY 10021-6399, USA.
International Journal of Clinical & Laboratory Research
|August 5, 1998
Summary
The apolipoprotein E 4/3 phenotype is linked to higher serum lipid peroxide levels compared to the E 3/2 phenotype. This suggests apolipoprotein E phenotypes may influence serum oxidation status differently.
Area of Science:
- Biochemistry
- Human Physiology
- Genetics
Background:
- Apolipoprotein E (ApoE) plays a role in lipid metabolism.
- Oxidative stress is implicated in various chronic diseases.
- The relationship between ApoE phenotypes and serum oxidation status requires further investigation.
Purpose of the Study:
- To investigate the association between apolipoprotein E (ApoE) levels and phenotypes with serum oxidation markers.
- To determine if ApoE phenotypes influence lipid peroxide and transition metal ion levels.
Main Methods:
- Assayed ApoE levels and phenotypes in sera from 182 healthy individuals (129 women, 53 men).
- Measured serum lipid peroxides, transition metal ions, and their binding proteins (ceruloplasmin, ferritin).
- Utilized statistical analyses including correlation and multivariate analysis.
Main Results:
- ApoE 4/3 phenotype subjects had higher lipid peroxide levels than E 3/2 phenotype subjects (P=0.015).
- ApoE 4/3 phenotype showed a significant association between ApoE and lipid peroxide levels (r=0.470, P<0.01).
- ApoE phenotype independently contributed to variation in serum lipid peroxide levels.
Conclusions:
- Apolipoprotein E phenotype heterogeneity may exist in relation to serum lipid oxidation status.
- The ApoE 4/3 phenotype is associated with increased serum lipid peroxidation.
- Further research is warranted to elucidate the clinical implications of these findings.