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Hemorheological parameters for biocompatibility evaluation

K Nageswari1, R Banerjee, R V Gupte

  • 1School of Biomedical Engineering, Indian Institute of Technology, Powai, Mumbai, India.

Journal of Biomaterials Applications
|August 5, 1998
PubMed
Summary
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Evaluating hemocompatibility is crucial for biomaterials. This study found that increased blood viscosity and altered biochemical parameters after material incubation indicate incompatibility, serving as a vital screening tool.

Area of Science:

  • Biomaterials Science
  • Hemocompatibility Testing
  • Biocompatibility Evaluation

Background:

  • Biomaterials are widely used in clinical settings.
  • Hemocompatibility testing is essential due to blood's sensitivity to foreign substances.
  • Current methods for biomaterial compatibility screening rely on blood viscosity parameters.

Purpose of the Study:

  • To evaluate the utility of blood viscosity parameters as screening tests for biomaterial hemocompatibility.
  • To identify key hemorheological and biochemical markers indicative of biomaterial incompatibility.

Main Methods:

  • Assessed whole blood viscosity, plasma viscosity, red cell rigidity, and hematocrit in samples (n=10).
  • Measured biochemical parameters including total proteins and albumin.

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  • Incubated blood samples with biomaterials to observe changes in measured parameters.

    • Main Results:

    • A significant increase in hemorheological parameters was observed after incubation with biomaterials.
    • Elevated blood viscosity and altered red cell rigidity suggest potential incompatibility.
    • Changes in biochemical parameters like total proteins and albumin may also correlate with incompatibility.

    Conclusions:

    • Blood viscosity parameters, including whole blood viscosity, plasma viscosity, red cell rigidity, and hematocrit, are effective indicators for screening biomaterial hemocompatibility.
    • Significant alterations in these parameters post-incubation signal material incompatibility, potentially reducing the need for extensive further testing.
    • This approach offers a valuable preliminary assessment for biomaterial safety in clinical applications.