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Effects of shock waves on the rat foetus
1Department of Urology, Firat University School of Medicine, Elaziğ, Turkey.
Scandinavian Journal of Urology and Nephrology
|August 5, 1998
Summary
Shock wave lithotripsy (SWL) poses risks during pregnancy. This study found SWL can cause fetal damage and death in rats, particularly in later pregnancy stages.
Area of Science:
- Reproductive Biology
- Toxicology
- Medical Physics
Background:
- The safety of shock wave lithotripsy (SWL) during pregnancy is debated.
- While shock wave effects on cells are known, fetal impact remains unclear.
Purpose of the Study:
- To investigate the effects of SWL on fetal development in a rat model.
- To assess dose-dependent and timing-dependent SWL impacts on pregnancy.
Main Methods:
- Pregnant rats received 100, 250, or 500 shock waves on days 8, 11, 14, or 17 of gestation.
- Fetal viability, histological changes, and tissue damage were evaluated.
Main Results:
- SWL exposure led to a range of fetal effects, from mild to fatal, depending on dose and gestational timing.
- No viable fetuses were observed in rats receiving 500 shock waves late in pregnancy.
- Histological examination revealed brain, lung, and subcutaneous tissue damage, including fusion and necrosis in deceased fetuses.
Conclusions:
- SWL can induce significant fetal damage and mortality in rats during late pregnancy.
- These findings suggest potential contraindications for SWL in pregnant patients, especially in later trimesters.