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Related Experiment Videos

Silent memory induction in maternal immune young animals

W J Boersma1, E M Van Rooij, J W Scholten

  • 1Department of Immunology & Virology, Institute for Animal Science and Health (ID-DLO), Lelystad, The Netherlands.

The Veterinary Quarterly
|August 5, 1998
PubMed
Summary

Maternal immunity in piglets does not transfer memory and vaccination can be ineffective. Maternal immunity can interfere with vaccination, highlighting the importance of colostrum and milk for protection beyond antibodies.

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Area of Science:

  • Veterinary Immunology
  • Animal Health
  • Vaccinology

Background:

  • Maternal immunity plays a crucial role in protecting neonatal animals.
  • The mechanisms and impact of maternal immunity on vaccination efficacy require further elucidation.
  • Porcine reproductive and respiratory syndrome virus (PRRSV) remains a significant threat to swine health.

Purpose of the Study:

  • To investigate the role of maternal immunity in piglets regarding vaccination efficacy.
  • To determine if maternal immunity involves the transfer of immunological memory.
  • To assess the impact of vaccination on maternally immune and immunosuppressed piglets.

Main Methods:

  • Vaccination of piglets with varying levels of maternal immunity.
  • Assessment of antibody formation and induction of immunological memory.

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  • Evaluation of protection against challenge, correlating with serum antibody titers.

    • Main Results:

    • Maternal immunity did not involve the transfer of memory and vaccination boosting was ineffective.
    • Transferred maternal immunity interfered with optimal vaccine-induced protection, inhibiting antibody formation.
    • Vaccination in young animals negatively impacted maternal immune protection; no correlation between serum antibody titers and protection was found.

    Conclusions:

    • Maternal immunity is an effector mechanism that does not transfer memory and can hinder vaccination.
    • Colostrum and milk provide protection through soluble factors and cellular immunity, independent of specific antibody titers.
    • Further research into non-antibody-mediated components of maternal immunity is warranted for effective disease control strategies.