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Cloning and sequencing of the bovine STAT5A cDNA reveals significant sequence divergence with ovine
P Schröder1, L Meyer, T T Wheeler
1Forschungsinstitut für die Biologie landwirtschaftlicher Nutztiere, Dummerstorf, Germany.
Biochimica Et Biophysica Acta
|August 5, 1998
Abstract:
The transcription factors STAT5 mediates prolactin signals in mammary epithelial cells. The cDNA of bovine STAT5A was cloned, sequenced and compared to other species. The encoded protein proves to be > 95% homologous to other mammals. We show that the STAT5A mRNA of the closely related ovine species contains an extended (by 130 nt) 5'-untranslated region, being encoded by an extra-exon, and accounts, possibly, for improved translation efficiency.