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A new model of renal microvascular injury
M Nangaku1, S J Shankland, W G Couser
1Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Japan. mnangaku-tky@umin.ac.jp
Current Opinion in Nephrology and Hypertension
|August 5, 1998
Abstract:
The vascular endothelial injury with its consequent activation is actively involved in inflammation and promotion of a procoagulant state, which are likely to be of major importance in the pathogenesis of various disorders, including renal thrombotic microangiopathy. This study briefly reviews the consequences of glomerular endothelial cell injury or activation, as shown by recent experimental data.