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Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
Published on: November 21, 2013
Novel antipsychotics, extrapyramidal side effects and tardive dyskinesia
1Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine, London, UK.
International Clinical Psychopharmacology
|August 5, 1998
Summary
Conventional antipsychotics cause motor side effects like parkinsonism and tardive dyskinesia, impacting patient compliance. Newer atypical antipsychotics show promise for reduced motor disturbances, potentially improving treatment adherence and long-term outcomes.
Area of Science:
- Psychiatry and Pharmacology
- Neuroscience
- Clinical Therapeutics
Background:
- Conventional antipsychotics are linked to significant motor disturbances, including acute extrapyramidal symptoms and chronic tardive dyskinesia.
- These movement disorders cause patient distress, reduce medication compliance, and complicate clinical assessments.
- The newer generation of atypical antipsychotics is suggested to have a lower risk of these adverse motor effects.
Purpose of the Study:
- To review available data on atypical antipsychotics concerning their adverse motor effects.
- To compare the motor side effect profiles of newer antipsychotics with conventional agents.
- To explore the potential of atypical antipsychotics in mitigating both acute and chronic movement disorders.
Main Methods:
- Review of clinical trial data for newer antipsychotic drugs (clozapine, risperidone, olanzapine, amisulpride, quetiapine, sertindole).
- Comparison of reported extrapyramidal symptom liability with conventional antipsychotics (haloperidol, chlorpromazine).
- Analysis of emerging evidence on the long-term motor effects, including tardive dyskinesia, associated with atypical antipsychotics.
Main Results:
- Clinical trials suggest newer antipsychotics have a lower incidence of acute extrapyramidal symptoms compared to conventional drugs.
- Direct comparative studies on the relative liability of newer agents for acute motor side effects are limited.
- Accumulating evidence indicates a potential for reduced risk of tardive dyskinesia with atypical antipsychotics, with clozapine showing promise.
Conclusions:
- Atypical antipsychotics appear to offer an improved motor side effect profile compared to conventional antipsychotics.
- Further comparative studies are needed to definitively establish the relative risks of acute motor side effects among newer agents.
- The potential for reduced long-term motor complications, such as tardive dyskinesia, represents a significant advancement in antipsychotic therapy.
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