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Practicable approaches to targeted comparative mapping of rat chromosome regions: linkage mapping of five genes on
1The Wellcome Trust Centre for Human Genetics, Oxford University, Oxford (UK). kato@helios.jinkan.kyoto-u.ac.jp
Cytogenetics and Cell Genetics
|August 6, 1998
Abstract:
We demonstrate feasible approaches to comparative mapping between the region near the renin locus on rat chromosome 13 and human chromosome 1q by assigning five additional genes as anchor loci. Base-substitution polymorphisms were sought in the 3'- and/or 5'-untranslated regions for subsequent development of PCR-amplified markers, which, in turn, could be used for either restriction fragment analysis or allele-specific PCR.