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[A case of marginal zone B-cell lymphoma]
1Department of Internal Medicine, Matsudo Municipal Hospital, Chiba, Japan.
Summary
This study identifies a rare case of malignant lymphoma in the lung, specifically a marginal zone B-cell lymphoma. The findings highlight lymphoepithelial lesions and B-cell markers in diagnosing this bronchus-associated lymphoid tissue tumor.
Area of Science:
- Oncology
- Pathology
- Immunology
Background:
- Malignant lymphomas can rarely manifest in the lung, originating from bronchus-associated lymphoid tissue.
- Accurate classification is crucial for appropriate patient management and understanding disease behavior.
Observation:
- A 60-year-old woman presented with an abnormal lung shadow on chest roentgenogram.
- Transbronchial biopsy and subsequent lobectomy revealed malignant lymphoma with lymphoepithelial lesions.
Findings:
- Flow cytometry identified tumor cells expressing B-cell antigens (CD19, CD20) but negative for CD5 and CD10.
- Immunoglobulin heavy chain gene rearrangement (Southern blot) confirmed monoclonal origin.
- The tumor was classified as marginal zone B-cell lymphoma per the European-American classification.
Implications:
- This case expands the understanding of extranodal marginal zone B-cell lymphomas.
- Highlights the importance of integrated diagnostic approaches, including immunophenotyping and molecular analysis, for lung lymphomas.
- Contributes to the literature on bronchus-associated lymphoid tissue lymphomas.