[Morphological signs of ineffective chemotherapy for experimental destructive pulmonary tuberculosis]

A rabbit model of destructive pulmonary tuberculosis was used to study the specific features of the cellular composition of the wall of the cavern and its adjacent lung parenchyma during long-term (as long as 6 months) chemotherapy. The morphological findings were compared with the dynamics of isolation of Mycobacteria tuberculosis which, including those unchanged, are one of the main causes of retarded healing processes. The morphological responses generally reflecting the ineffective chemotherapy of destructive pulmonary tuberculosis were identified.