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[Comprehensive medicine and 17-KS-S]
K Nagata1, K Morishita, M Yamazaki
1Health Administration Center and Psychosomatic Medicine, Hamamatsu University, School of Medicine.
Rinsho Byori. the Japanese Journal of Clinical Pathology
|August 6, 1998
Summary
This study explored the relationship between urinary steroid metabolites and quality of life (QOL) in patients and nurses. Findings suggest that levels of 17-KS-S (S), 17-OHCS (OH), and their ratio (S/OH) can objectively evaluate QOL.
Area of Science:
- Endocrinology
- Psychoneuroimmunology
- Comprehensive Medicine
Context:
- Quality of Life (QOL) assessment is crucial in healthcare.
- Urinary steroid metabolites, including 17-KS-S (S) and 17-OHCS (OH), are potential biomarkers.
- Previous research has explored stress markers and QOL, but the specific relationship with S, OH, and S/OH requires further investigation.
Purpose:
- To investigate the correlation between urinary steroid metabolites (S, OH, S/OH) and self-rated Quality of Life (QOL) in patients and nurses.
- To determine if these metabolites can serve as objective indicators for evaluating QOL.
Summary:
- A study involving 268 patients and 31 nurses examined self-rated QOL alongside urinary 17-KS-S (S), 17-OHCS (OH), and S/OH ratios.
- Patients exhibited lower S and S/OH, and higher OH levels, correlating with lower QOL scores.
- Nurses showed lower S and S/OH, and lower OH levels, correlating with higher QOL scores.
- In terminally ill cancer patients receiving supplementary treatments, an elevation in S was observed during the study period.
Impact:
- The findings suggest that urinary steroid metabolites (S, OH, S/OH) are significantly related to QOL.
- These metabolites may offer an objective method for assessing and monitoring QOL in clinical settings.
- This research contributes to a more comprehensive understanding of QOL from a biological perspective within comprehensive medicine.