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Essential Cys-Pro-Cys motif of Caenorhabditis elegans copper transport ATPase
T Yoshimizu1, H Omote, T Wakabayashi
1Division of Biological Sciences, Osaka University, Japan.
Bioscience, Biotechnology, and Biochemistry
|August 6, 1998
Abstract:
Caenorhabditis elegans putative copper ATPase (CUA-1) had been functionally expressed in a yeast delta ccc2 mutant (copper ATPase gene disruptant). We found that CUA-1 with Cys-Pro-Cys to Cys-Pro-Ala mutation could not rescue the yeast delta ccc2 mutant, suggesting that the carboxyl terminal cysteine residue in the conserved Cys-Pro-Cys motif is essential for copper transport.