Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lung retransplantation in children

C B Huddleston1, E N Mendeloff, A H Cohen

  • 1Division of Cardiothoracic Surgery, Washington University School of Medicine, St. Louis Children's Hospital, USA. huddleston_c@a1.kids.wustl.edu

The Annals of Thoracic Surgery
|August 6, 1998
PubMed
Summary

Lung retransplantation in children is a viable option for severe graft dysfunction, offering a chance for survival. Living donor transplants in older children may improve outcomes despite higher risks.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A systematic approach to transplanting non-resident, non-citizens in an established US pediatric lung transplant program.

International journal of pediatrics & adolescent medicine·2022
Same author

Haemodynamic characterisation and heart catheterisation complications in children with pulmonary hypertension: Insights from the Global TOPP Registry (tracking outcomes and practice in paediatric pulmonary hypertension).

International journal of cardiology·2015
Same author

Lung transplantation--looking beyond 1-year survival.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2014
Same author

A multicenter study of primary graft failure after infant heart transplantation: impact of extracorporeal membrane oxygenation on outcomes.

Pediatric transplantation·2014
Same author

Pediatric lung allocation: the rest of the story.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2013
Same author

Psychological adjustment of pediatric lung transplantation candidates and their parents.

Journal of clinical psychology in medical settings·2013

Area of Science:

  • Pediatric surgery
  • Thoracic surgery
  • Transplantation immunology

Background:

  • Lung transplantation in children can fail early due to reperfusion injury or late from bronchiolitis obliterans.
  • Graft failure can lead to worsening pulmonary dysfunction and recipient death, often necessitating retransplantation.
  • While adult lung retransplantation outcomes are established, pediatric data is less defined.

Purpose of the Study:

  • To review the outcomes of lung retransplantation in pediatric patients.
  • To compare retransplantation procedures with primary lung transplants in children.
  • To evaluate the impact of donor type (living related vs. cadaveric) on retransplantation success.

Main Methods:

  • Retrospective review of 136 pediatric lung transplant procedures.

Related Experiment Videos

  • Analysis of 14 pediatric lung retransplantations, including 6 for early graft failure and 8 for bronchiolitis obliterans.
  • Comparison of operative data (bypass time, blood transfusion) and survival rates between primary and retransplant procedures.

    • Main Results:

    • Actuarial survival at 2 years post-retransplantation was 58%, with 3 early and 3 late deaths.
    • Retransplantation involved longer cardiopulmonary bypass times and greater blood transfusion volumes compared to primary transplants.
    • Living related donor lung retransplants demonstrated significantly shorter ischemic times than cadaveric donor transplants.

    Conclusions:

    • Lung retransplantation is a reasonable therapeutic option for children with severe graft dysfunction.
    • Living donor lung transplantation in older children may offer advantages for retransplantation.
    • Further research is needed to optimize outcomes and mitigate risks associated with pediatric lung retransplantation.