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Interdigestive antroduodenal motility and gastric acid secretion
H A Gielkens1, A Nieuwenhuizen, I Biemond
1Department of Gastroenterology-Hepatology, Leiden University Medical Centre, The Netherlands.
Alimentary Pharmacology & Therapeutics
|August 6, 1998
Summary
Acute acid inhibition using famotidine does not alter interdigestive antroduodenal motility. This study found no significant changes in the migrating motor complex (MMC) cycle during acid suppression.
Area of Science:
- Gastroenterology
- Human Physiology
- Pharmacology
Background:
- Interdigestive gastric acid secretion and antroduodenal motility exhibit cyclic variations, synchronized with the migrating motor complex (MMC).
- Duodenal acidification is known to inhibit antral motility, but the impact of acute acid inhibition on antroduodenal motility remains unclear.
Purpose of the Study:
- To investigate the effects of acute acid inhibition on interdigestive antroduodenal motility.
Main Methods:
- Ten healthy volunteers underwent simultaneous measurement of antroduodenal motility (perfusion manometry) and gastric acid secretion.
- Subjects were studied twice: once with intravenous saline infusion and once with intravenous famotidine for acute acid inhibition, covering at least two MMC cycles.
Main Results:
- Famotidine effectively increased gastric pH above 6 within 30 minutes.
- No significant differences were observed in the duration or phase distribution of the MMC cycle between the famotidine and saline conditions.
Conclusions:
- Gastric acid secretion naturally fluctuates cyclically with interdigestive antroduodenal motility.
- Acute acid inhibition via intravenous famotidine does not significantly impact interdigestive antroduodenal motility patterns.