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[Sneddon syndrome new clinical and immunological data]
Klinicheskaia Meditsina
|August 7, 1998
Summary
This study found IgG-antibodies to prothrombin (aPT) in Sneddon's syndrome patients. These antibodies may indicate a lower risk of thrombosis and a less severe disease course in patients with antiphospholipid antibodies.
Area of Science:
- Immunology
- Neurology
- Rheumatology
Background:
- Sneddon's syndrome is a rare condition characterized by livedo reticularis and neurological deficits.
- Antiphospholipid antibodies (aPL) are frequently observed in Sneddon's syndrome, suggesting a link to antiphospholipid syndrome (APS).
- The role of specific aPL, such as antibodies to prothrombin (aPT), in the pathogenesis and clinical manifestation of Sneddon's syndrome requires further investigation.
Purpose of the Study:
- To investigate the prevalence of IgG-antibodies to prothrombin (aPT) in patients with Sneddon's syndrome.
- To explore the association between aPT and other antiphospholipid antibodies (aPL), including anticardiolipin (aCL) and lupus anticoagulant (LA).
- To evaluate the clinical significance of aPT in Sneddon's syndrome, particularly concerning thrombosis risk and disease severity.
Main Methods:
- Enzyme immunoassay was used to detect IgG-antibodies to prothrombin (aPT) in 47 patients with Sneddon's syndrome.
- Other aPL, including aCL and LA, were also assessed.
- Patients were analyzed for the presence of at least one aPL, and subgroups were compared based on dominant antigenic specificity.
Main Results:
- IgG-antibodies to prothrombin (aPT) were detected in 27 out of 47 (57%) Sneddon's syndrome patients.
- A significant correlation was observed between aPT and LA, with LA being more prevalent in aPT-positive patients (p < 0.05).
- Patients with aPT, particularly those without aCL, showed a lower frequency of cerebral circulation disorders, headaches, dementia, and renal syndrome compared to patients with aCP but without aPT.
Conclusions:
- The presence of aPT in Sneddon's syndrome may serve as a marker for a comparatively lower risk of thrombosis.
- aPT positivity in Sneddon's syndrome appears to be associated with a less severe clinical course of the disease.
- These findings highlight the potential role of prothrombin as a cofactor in the pathogenesis of Sneddon's syndrome and its association with antiphospholipid syndrome.