[State of the exocrine function of the pancreas during human aging]

A study of the exacrinous function of the pancreas made in 205 healthy persons aged from 18 to 90 has evidenced that in ageing there takes place in the duodenal mixture of juices a statistically significant decline in the activity of trypsin and of its inhibitor, lipase, amylase, in the level of bicarbonates and in the volume of the juice along with an increase in the content of chlorides. In ageing more marked changes become apparent following application of the agents stimulating the pancreatic secretion of the secretin and pancreozymin mechanism of action, and then the greatest changes are seen to occur on the level of lipase and trypsin and the least -- on the level of the amylase activity and the bicarbonate alkalinity content. Note has also been taken of an age-specific statistically significant decline in the activity of the studied pancreatic enzymes in the blood (trypsin, its inhibitor, lipase, amylase) and in the urine (lipase, amylase).