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SHP-2, SH2-containing protein tyrosine phosphatase-2
M Stein-Gerlach1, C Wallasch, A Ullrich
1Department of Molecular Biology, Max-Planck-Institute for Biochemistry, Martinsried, Germany.
The International Journal of Biochemistry & Cell Biology
|August 7, 1998
Summary
SHP-2 (Src homology 2 domain-containing phosphatase-2) is a key protein in cell signaling, often promoting cell growth. Its role in cancer suggests it could be a therapeutic target for cancer treatment.
Area of Science:
- Biochemistry
- Molecular Biology
- Cell Signaling
Background:
- SHP-2 is a widely distributed cytosolic protein tyrosine phosphatase.
- It possesses SH2 domains, a phosphatase domain, and a C-terminal tail.
- SHP-2 interacts with various tyrosine-phosphorylated molecules upon cell activation.
Purpose of the Study:
- To elucidate the function of SHP-2 in cellular signaling pathways.
- To investigate the potential role of SHP-2 in tumorigenesis.
- To explore SHP-2 as a potential therapeutic target in cancer treatment.
Main Methods:
- Analysis of SHP-2 interactions with receptor tyrosine kinases, adapter proteins, and cell adhesion molecules.
- Investigation of SHP-2's role in signal transduction cascades.
- Exploration of SHP-2's involvement in cell growth and cancer development.
Main Results:
- SHP-2 acts as a positive mediator in signals from activated membrane receptor complexes.
- The diverse binding partners and substrates of SHP-2 suggest multifaceted functions.
- SHP-2's positive regulatory role in cell growth pathways is implicated in tumorigenesis.
Conclusions:
- SHP-2 plays a significant role in promoting cell growth signals.
- Its involvement in cancer development makes it a potential therapeutic target.
- Further research is needed to fully understand SHP-2's complex functions and inhibitory mechanisms.