Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Psoriasin (S100A7)

P H Watson1, E R Leygue, L C Murphy

  • 1Department of Pathology, University of Manitoba, Winnipeg, Canada.

The International Journal of Biochemistry & Cell Biology
|August 7, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Factors that drive the increasing use of FFPE tissue in basic and translational cancer research.

Biotechnic & histochemistry : official publication of the Biological Stain Commission·2018
Same author

Half-Yearly Report of Cases Occurring at the Edinburgh Eye Infirmary.

Edinburgh medical journal·2018
Same author

The path of screw insertion for stabilization of the scapholunate joint: a cadaveric study.

Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand·2014
Same author

Oncostatin-M promotes phenotypic changes associated with mesenchymal and stem cell-like differentiation in breast cancer.

Oncogene·2013
Same author

Expression of both estrogen receptor-beta 1 (ER-β1) and its co-regulator steroid receptor RNA activator protein (SRAP) are predictive for benefit from tamoxifen therapy in patients with estrogen receptor-alpha (ER-α)-negative early breast cancer (EBC).

Annals of oncology : official journal of the European Society for Medical Oncology·2013
Same author

Tumour-infiltrating FOXP3(+) lymphocytes are associated with cytotoxic immune responses and good clinical outcome in oestrogen receptor-negative breast cancer.

British journal of cancer·2012
Same journal

Corrigendum to "Sodium butyrate down-regulation of indoleamine 2, 3-dioxygenase at the transcriptional and post-transcriptional levels" [Int. J. Biochem. Cell Biol. 42 (2010) 1840-1846].

The international journal of biochemistry & cell biology·2026
Same journal

Whole-brain spatial metabolomics reveals metabolic gradient shifts in a murine glioma model following boron neutron capture therapy (130 characters).

The international journal of biochemistry & cell biology·2026
Same journal

LCN2 modulates Th17/Treg balance in vitro and is associated with an adaptive response to intestinal ischemia-reperfusion injury under Hmox1-deficient conditions.

The international journal of biochemistry & cell biology·2026
Same journal

Chloroquine modulates the redox-sensitive signalling via inhibiting the AMPK-ULK1 under LPS induced state in murine splenic macrophages.

The international journal of biochemistry & cell biology·2026
Same journal

The vicious cycle of hyperglycemia and oxidative stress: Novel mechanistic insights into a pathogenic alliance.

The international journal of biochemistry & cell biology·2026
Same journal

Fibroblast growth factors (FGF) in the pathogenesis and treatment of inflammatory bowel diseases (IBD): An overview.

The international journal of biochemistry & cell biology·2026
See all related articles

Psoriasin (S100A7) is a protein involved in inflammatory skin conditions like psoriasis and early breast tumor progression. It shows potential as a diagnostic marker for squamous cell carcinoma and distinguishing breast cancer stages.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Psoriasin (S100A7) is a calcium-binding protein belonging to the S100 gene family, located on chromosome 1q21.
  • Initially identified in psoriatic skin, it's now known to be expressed in keratinocytes and malignant breast epithelial cells.

Purpose of the Study:

  • To investigate the role of psoriasin (S100A7) in inflammatory skin diseases and breast cancer progression.
  • To explore its potential as a diagnostic and detection marker.

Main Methods:

  • Expression analysis in normal and malignant keratinocytes and breast epithelial cells.
  • Review of current evidence on psoriasin's function in pathogenesis.

Main Results:

  • Psoriasin (S100A7) is associated with abnormal differentiation pathways in keratinocytes and breast cancer.

Related Experiment Videos

  • It acts as a chemotactic factor for hematopoietic cells, contributing to inflammatory skin disease.
  • Evidence suggests a role in early breast tumor progression and the development of invasive phenotypes.

    • Conclusions:

    • Psoriasin (S100A7) plays a role in inflammatory skin conditions and breast cancer progression.
    • It holds potential as a detection marker for squamous cell carcinoma and a diagnostic tool for breast cancer staging.