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Related Experiment Videos

The ependyma in chronic hydrocephalus

M Kiefer1, R Eymann, S von Tiling

  • 1Department of Neurosurgery, Saarland University, Homburg, Germany. michael.kiefer@metronet.de

Child'S Nervous System : Chns : Official Journal of the International Society for Pediatric Neurosurgery
|August 7, 1998
PubMed
Summary

Congenital hydrocephalus in H-Tx rats leads to ependymal damage, with reduced microvilli and cilia. Despite limited recovery potential, a novel supraependymal network may stabilize the ventricular system.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Pathology

Background:

  • H-Tx rats exhibit congenital hydrocephalus with variable severity.
  • Studied moderately hydrocephalic rats and normal controls at least 1.5 years old.

Purpose of the Study:

  • Investigate ependymal ultrastructure in arrested hydrocephalus.
  • Characterize anatomical and ultrastructural changes in the hydrocephalic brain.

Main Methods:

  • Magnetic Resonance Imaging (MRI) for macroscopic anatomy.
  • Examination of fixed brain slices.
  • Scanning Electron Microscopy (REM) for ependymal ultrastructure.

Main Results:

  • Ependymal destruction observed in stretched areas, exposing subependymal structures to cerebrospinal fluid (CSF).

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  • Reduced density of ependymal microvilli and cilia correlated with ventricular distension.
  • A novel supraependymal network was identified, potentially limiting further ventricular enlargement.

    • Conclusions:

    • Ependymal damage in arrested hydrocephalus resembles acute stages, indicating limited recovery potential.
    • The organism exhibits compensatory mechanisms, including a supraependymal network, for internal stabilization of the ventricular system.