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Cell Population Analyses During Skin Carcinogenesis
Published on: August 21, 2013
Specific distribution patterns of hCDC47 expression in cutaneous diseases
A Hiraiwa1, M Fujita, A Adachi
1Department of Dermatology, Nagoya University School of Medicine, Japan. ahiraiwa@tsuru.med.nagoya-u.ac.jp
Journal of Cutaneous Pathology
|August 7, 1998
Summary
Human CDC47 (hCDC47) expression was studied in skin tumors and proliferative diseases. Higher hCDC47 rates were found in keratoacanthomas and verruca vulgaris, suggesting its role in keratinocyte proliferation.
Area of Science:
- Dermatology
- Molecular Biology
- Oncology
Background:
- hCDC47, a human MCM family member, is involved in DNA replication regulation.
- Previous studies indicated hCDC47 expression in normal tissue's proliferative cells and elevated levels in squamous cell skin carcinomas.
Purpose of the Study:
- To compare hCDC47 expression in different skin tumors and non-neoplastic proliferative conditions.
- To investigate the distribution patterns of hCDC47 in various cutaneous disorders.
Main Methods:
- Immunohistochemical analysis of hCDC47 expression in tissue samples.
- Quantification of hCDC47 positive cell rates in keratoacanthomas, verruca vulgaris, psoriasis vulgaris, and basal cell carcinoma.
Main Results:
- Two distinct hCDC47 distribution patterns were observed: peripheral and diffuse.
- Keratoacanthomas (43.1%) and verruca vulgaris (42.5%) showed the highest hCDC47 positive cell rates.
- Psoriasis vulgaris (23.4%) and basal cell carcinoma (17.3%) exhibited lower, but significant, hCDC47 expression.
Conclusions:
- hCDC47 expression patterns vary across different proliferative skin conditions.
- The findings suggest hCDC47 plays a role in keratinocyte proliferation in diseases like keratoacanthoma and verruca vulgaris.
