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Updated: Oct 2, 2026

Intranasal Administration of CNS Therapeutics to Awake Mice
Published on: April 8, 2013
Nasal airflow in growth hormone treatment
1Department of Otorhinolaryngology, Mölndal Hospital, Sweden.
Abstract:
Nasal congestion due to hormonal influences has been recognized as a clinical entity, and a "hormonal rhinitis" has been proposed to occur in acromegaly. In this study we investigated the effect of low-dose recombinant human growth hormone over eight weeks on nasal congestion as measured by nasal peak flow in a randomized, placebo-controlled, double-blind crossover clinical trial in ten patients with short bowel syndrome. The treatment did not induce a significant nasal congestion. Whether higher doses as used in many catabolic conditions do remains to be determined.
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