Nasal airflow in growth hormone treatment

Nasal congestion due to hormonal influences has been recognized as a clinical entity, and a "hormonal rhinitis" has been proposed to occur in acromegaly. In this study we investigated the effect of low-dose recombinant human growth hormone over eight weeks on nasal congestion as measured by nasal peak flow in a randomized, placebo-controlled, double-blind crossover clinical trial in ten patients with short bowel syndrome. The treatment did not induce a significant nasal congestion. Whether higher doses as used in many catabolic conditions do remains to be determined.