Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

CD21/CD35 in B cell activation

M C Carroll1

  • 1Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.

Seminars in Immunology
|August 8, 1998
PubMed
Summary
This summary is machine-generated.

B cell receptor signaling strength influences naive B cell fate. The complement system, via C3d binding to CD21, is crucial for B cell responses and survival.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Invasion of spontaneous germinal centers by naive B cells is rapid and persistent.

bioRxiv : the preprint server for biology·2023
Same author

The origin and stability of nanostructural hierarchy in crystalline solids.

Science advances·2018
Same author

B cell tolerance to epidermal ribonuclear-associated neo-autoantigen in vivo.

Clinical and experimental immunology·2017
Same author

THE ROLE OF SPECIFIC IgG AND COMPLEMENT IN COMBATING A PRIMARY MUCOSAL INFECTION OF THE GUT EPITHELIUM.

European journal of microbiology & immunology·2012
Same author

The role of complement and natural antibody in intestinal ischemia-reperfusion injury.

International journal of immunopathology and pharmacology·2003
Same author

Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.

Clinical immunology (Orlando, Fla.)·2001
Same journal

Myeloid cells as sources and targets of IL-1 family cytokines in cancer.

Seminars in immunology·2026
Same journal

Interleukin-1-mediated inflammatory memory: Protective training or maladaptive tumor imprinting?

Seminars in immunology·2026
Same journal

Chronic stress at the crossroads: Decoding the HPA-SAM-immune-gut axis in inflammatory bowel disease pathogenesis and therapeutics.

Seminars in immunology·2026
Same journal

Protein tyrosine kinases in dendritic cell-mediated anti-cancer immunity.

Seminars in immunology·2026
Same journal

The immune system in Latin America and the Caribbean: Insights into diseases and diversity from local perspectives.

Seminars in immunology·2026
Same journal

Introduction to the special issue: T<sub>H</sub>9 cells in diseases.

Seminars in immunology·2026
See all related articles

Area of Science:

  • Immunology
  • Cell Biology
  • Innate Immunity

Background:

  • B cell receptor (BCR) signaling dictates naive B cell activation, elimination, or anergy.
  • Signal transduction strength depends on antigen affinity and co-receptor signals (CD21/CD19/Tapa-1).

Purpose of the Study:

  • To investigate the role of CD21 co-receptor signaling in B cell fate and humoral immune responses.

Main Methods:

  • The abstract does not specify methods.

Main Results:

  • Absence of CD21 on B cells impairs humoral responses to T-dependent antigens.
  • CD21 deficiency leads to reduced B cell follicular retention and germinal center survival.
  • Complement C3d, the ligand for CD21, is attached to antigen upon complement system activation.

Related Experiment Videos

Conclusions:

  • The complement system is a critical regulator of B lymphocyte function.
  • CD21-mediated signaling is essential for effective B cell activation, survival, and antibody production.