Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dissolution of multicomponent microbubbles in the bloodstream: 2. Experiment

A Kabalnov1, J Bradley, S Flaim

  • 1Alliance Pharmaceutical Corporation, San Diego, CA 92121, USA. ask@allp.com

Ultrasound in Medicine & Biology
|August 8, 1998
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intermittent Fasting Regimes Reduce Gingival Inflammation: A Three-Arm Clinical Trial.

Journal of clinical periodontology·2025
Same author

Is mapping the BCG vaccine-induced immune responses the key to improving the efficacy against tuberculosis?

Journal of internal medicine·2020
Same author

Short- and Long-term Outcome After Interventional VSD Closure: A Single-Center Experience in Pediatric and Adult Patients.

Pediatric cardiology·2020
Same author

[A boy with white sponge naevus of the buccal mucosa].

Nederlands tijdschrift voor geneeskunde·2020
Same author

Female patients are less satisfied with biological treatment for psoriasis and experience more side-effects than male patients: results from the prospective BioCAPTURE registry.

Journal of the European Academy of Dermatology and Venereology : JEADV·2019
Same author

Pear-Shaped Lesion of the Fossa of Rosenmüller.

Journal of the Belgian Society of Radiology·2018

Microbubble persistence in blood depends on filling gas molecular weight, with optimal ultrasound scattering from gases of intermediate weight. Persistence is primarily governed by gas dissolution, not RES removal.

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Ultrasound Contrast Agents

Background:

  • Microbubbles are crucial as ultrasound contrast agents.
  • Their persistence in the bloodstream affects diagnostic efficacy.
  • The choice of filling gas influences microbubble stability and performance.

Purpose of the Study:

  • To investigate how the filling gas affects microbubble persistence in blood.
  • To correlate filling gas properties with microbubble stability and ultrasound scattering.
  • To determine the primary mechanism controlling microbubble lifespan.

Main Methods:

  • Microbubbles with identical shells were filled with various perfluorocarbons and perfluoropolyethers, alone or with nitrogen.
  • Persistence time (tau) in bloodstream was measured.

Related Experiment Videos

  • Ultrasound scattering efficacy was assessed.
  • Experimental data was compared with a theoretical model.

    • Main Results:

    • Microbubble persistence increased with filling gas molecular weight up to a point, then decreased.
    • Optimal ultrasound scattering was observed for gases with intermediate molecular weights, high vapor pressure, and low water solubility.
    • Persistence time ranged from approximately 2 minutes to over 40 minutes.

    Conclusions:

    • Microbubble persistence is mainly controlled by gas dissolution, not reticuloendothelial system removal.
    • Experimental findings align qualitatively with theoretical predictions, with quantitative differences noted.
    • Filling gas selection is critical for optimizing microbubble-based ultrasound imaging.