[Changes in the antioxidant system of the vitreous in rabbits after administration of sulfur hexafluoride]
Related Experiment Video
Updated: Oct 28, 2026
Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
Published on: April 3, 2016
T Sztarbała1, R Goś, J Kedziora
1Kliniki Okulistycznej, Szpitala Klinicznego WAM w Lodzi.
Purpose:
To evaluate the enzymatic activity of antioxidant system of rabbit's vitreous after sulfur hexafluoride (SF6) application.
Material And Methods:
Activity of CuZn-SOD, catalase and concentration of MDA in fluid and gel fraction of vitreous were determined in 24 rabbits of New Zealand race on the 2nd, 7th and 14th day after SF6 application. Control group consisted of 6 animals which did not undergo any operations.
Results:
Dismutase and catalase activity as well as MDA concentration were higher in fluid fraction than in gel fraction in animals of control group. After SF6 application the activity of enzymes and MDA concentration did not change, whereas in fluid fraction all these values were statistically significantly reduced in all time intervals.
Conclusions:
SF6 leads to disintegration of vitreous structure especially just after its application. Damage to hyalocytes causes dysfunction of enzymatic system. Specific fluid fraction structure and insufficient number of substrates for peroxidation processes are the reasons for simultaneous reduction of MDA concentration.
