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Related Experiment Videos

Does histamine stimulate trigeminal nasal afferents?

S Sekizawa1, H Tsubone, M Kuwahara

  • 1Department of Comparative Pathophysiology, The University of Tokyo, Japan.

Respiration Physiology
|August 8, 1998
PubMed
Summary

Histamine stimulates nasal afferent nerve fibers in guinea pigs, but only when the nasal mucosa is damaged. This response is mediated by H1 receptors, indicating abnormal conditions are necessary for histamine

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Physiology

Background:

  • Histamine plays a role in nasal sensory nerve responses.
  • The specific receptors and conditions triggering these responses are not fully understood.

Purpose of the Study:

  • To investigate the response of nasal afferents to histamine in guinea pigs.
  • To determine the histamine receptor type involved in nasal sensory nerve activation.
  • To explore the conditions under which nasal mucosa responds to histamine.

Main Methods:

  • Recording electrical activity of the whole ethmoidal nerve (EN) and single units in anesthetized guinea pigs.
  • Intranasal instillation of histamine after pretreatment with saline, HCl, or H2SO4.
  • Pharmacological blockade using tripelennamine (H1 antagonist) and cimetidine (H2 antagonist).

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Main Results:

  • Histamine did not stimulate EN activity after saline pretreatment.
  • Histamine dose-dependently stimulated EN activity following HCl or H2SO4 pretreatment.
  • Tripelennamine blocked histamine's effect, while cimetidine did not, indicating H1 receptor mediation.
  • Single unit recordings showed a prolonged stimulatory effect of histamine after HCl pretreatment.

Conclusions:

  • The ethmoidal nerve (EN) in guinea pigs contains histamine-sensitive fibers.
  • Histamine's effect on these fibers is mediated by H1 receptors.
  • These histamine-sensitive fibers only respond under abnormal nasal mucosal conditions.