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In situ hybridization: a possible diagnostic aid in leptomeningeal metastasis
R J van Oostenbrugge1, A H Hopman, F C Ramaekers
1Department of Neurology, University Hospital Maastricht, The Netherlands.
Journal of Neuro-Oncology
|August 8, 1998
Abstract:
In this review we discuss the clinical features and pathophysiology of leptomeningeal metastasis (LM), and elaborate on diagnostic tools for the detection of this serious complication of cancer. Because of the low sensitivity of the cytologic examination, new diagnostic approaches have been developed. The in situ hybridization technique may prove to be a reliable and early test for the detection of LM.