Quality control in manufacturing process by near infrared spectroscopy
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Updated: Oct 28, 2026

O-cresol Concentration Online Measurement Based On Near Infrared Spectroscopy Via Partial Least Square Regression
Published on: November 8, 2019
1Quality Control Department, Laboratorios Almirall, S.A. Crta. Nacional II, Barcelona, Spain.
Abstract:
The combination of a pattern recognition technique with near infrared spectroscopy (NIR) to determine the conformity of a pharmaceutical mixture can be used in the routine checking of a pharmaceutical product. All the chemical and physical characteristics of the product that influence the NIR spectrum affect the qualification. The qualification is used to determine several deviations in the process: moisture, particle size and non-homogeneity. This work presents a method for the qualification analysis of a pharmaceutical mixture using the standard software of the instrument and a new program (DISPLOT). This program allows the acquisition of the plot of the scaled distances with its sign vs the wavelength.
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