Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

RAS pathways to cell cycle control and cell transformation

M Malumbres1, A Pellicer

  • 1Department of Pathology and Kaplan Comprehensive Cancer Center, New York University Medical Center, 550 First Avenue, New York, USA.

Frontiers in Bioscience : a Journal and Virtual Library
|August 11, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Psychosocial and environmental motivational key factors behind the parenthood desire in infertile couples at the time of COVID-19.

Journal of assisted reproduction and genetics·2024
Same author

Severe pulmonary hypertension and circulatory failure associated with Congenital syphilis. Case report.

Journal of neonatal-perinatal medicine·2024
Same author

RISEinFAMILY project: the integration of families at neonatal intensive care units (NICUs) to empower them as primary caregivers: study protocol for a stepped wedge cluster controlled trial.

Trials·2024
Same author

Correction to: The HERA (Hyper‑response Risk Assessment) Delphi consensus for the management of hyper‑responders in in vitro fertilization.

Journal of assisted reproduction and genetics·2023
Same author

The HERA (Hyper-response Risk Assessment) Delphi consensus for the management of hyper-responders in in vitro fertilization.

Journal of assisted reproduction and genetics·2023
Same author

Mosaic results after preimplantation genetic testing for aneuploidy may be accompanied by changes in global gene expression.

Frontiers in molecular biosciences·2023
Same journal

The CD44 protein family: roles in embryogenesis and tumor progression.

Frontiers in bioscience : a journal and virtual library·2017
Same journal

Four varieties of voltage-gated proton channels.

Frontiers in bioscience : a journal and virtual library·2017
Same journal

Lurie's tubercle-count method to test TB vaccine efficacy in rabbits.

Frontiers in bioscience : a journal and virtual library·2017
Same journal

Optical spectroscopy of breast biopsies and human breast cancer xenografts in nude mice.

Frontiers in bioscience : a journal and virtual library·2017
Same journal

The colostrum-deprived, artificially-reared, neonatal pig as a model animal for studying rotavirus gastroenteritis.

Frontiers in bioscience : a journal and virtual library·2017
Same journal

Action of polypeptide growth factors in colon cancer; development of new therapeutic approaches.

Frontiers in bioscience : a journal and virtual library·2017
See all related articles

Ras proteins, frequently activated oncogenes in cancer, regulate cell cycle progression. This review details recent advances in Ras signal transduction, focusing on its control over cell cycle regulators like cyclins and CDK inhibitors.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Signaling

Background:

  • Ras genes are frequently activated oncogenes in human cancers.
  • Ras proteins are key signal transducers in mammalian cells.
  • Ras signaling influences cellular responses like proliferation, differentiation, and apoptosis.

Purpose of the Study:

  • To review recent advances in Ras signal transduction pathways.
  • To highlight the role of Ras in controlling cell cycle progression.
  • To examine Ras interactions with cell cycle regulators.

Main Methods:

  • Literature review of recent scientific publications.
  • Analysis of Ras protein interactions and downstream effectors.
  • Focus on Ras-mediated regulation of cell cycle components.

Related Experiment Videos

Main Results:

  • Ras activation impacts diverse cellular processes, including cell cycle control.
  • Ras influences both positive and negative regulators of cyclin-dependent kinases (CDKs).
  • Ras targets cyclins and CDK inhibitors, affecting cell cycle progression.

Conclusions:

  • Ras signaling is central to understanding cancer development.
  • Ras-mediated regulation of the cell cycle is complex and multifaceted.
  • Ras pathways offer insights into intricate cellular signal transduction networks.