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[Antidepressants and sexual stimulation: the correlation]

S Chebili1, A Abaoub, B Mezouane

  • 1Psychiatre des Hôpitaux, EPS Ville Evrard, Neuilly-sur-Marne.

L'Encephale
|August 11, 1998
PubMed
Summary

This study explores how antidepressants affect sexual function. Certain antidepressants like viloxazine and moclobemide show promise in improving sexual drive and function, unlike doxepin due to side effects.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Human Sexuality

Background:

  • Sexual function involves complex neuromediator systems, including adrenergic, cholinergic, dopaminergic, and serotoninergic pathways.
  • Antidepressant medications can influence these neurotransmitter systems, potentially impacting sexual function.

Purpose of the Study:

  • To investigate the correlation between antidepressant treatments and sexual stimulation.
  • To describe the physiological aspects of sexual function and the role of neuromediators.

Main Methods:

  • A double-blind study evaluated the effects of viloxazine, an atypical antidepressant.
  • Analysis of existing studies on moclobemide and its impact on sexual function components.
  • Review of "corrector" drugs like yohimbine, cyproheptadine, amantadine, and bethanechol.

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Main Results:

  • Viloxazine may specifically enhance sex drive through a disinhibiting effect.
  • Moclobemide significantly improved all components of sexual function in a precise study.
  • Doxepin's numerous side effects limit its prescription for sexual dysfunction.

Conclusions:

  • Viloxazine and moclobemide show potential for specific effects on different aspects of sexual activity.
  • Further research into viloxazine and moclobemide is warranted for treating antidepressant-induced sexual dysfunction.
  • The use of "corrector" drugs for sexual dysfunction remains limited despite their availability.