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Alpha-2 macroglobulin is genetically associated with Alzheimer disease

D Blacker1, M A Wilcox, N M Laird

  • 1Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, USA.

Nature Genetics
|August 11, 1998
PubMed
Summary

A deletion in the Alpha-2-macroglobulin (A2M) gene increases Alzheimer disease risk. This genetic link suggests A2M may play a role in Alzheimer disease development, similar to APOE-epsilon4.

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