[Stomach motility and lyspafen]

Studies of motility of the stomach in 10 test-persons resulted in a significant reduction of motility after a 2-day period of perorally intake of Lyspafen. The active motoric substance is diffenoxin-hydrochloride. An addition of 0,025 mg Atropin sulfate could increase the effect. The effect is independent of the clinical diagnose. A "runaway" could be explained by an intolerance against lactose. The waves of type I are less influenced, such as the frequency of the waves of contraction.