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Updated: Aug 19, 2026

Peptide-based Identification of Functional Motifs and their Binding Partners
Published on: June 30, 2013
Immune dysfunction and the pathogenesis of AIDS-associated non-Hodgkin's lymphoma
O Martínez-Maza1, D Widney, M van der Meijden
1Department of Microbiology, UCLA School of Medicine 90095-1747, USA.
Abstract:
Much has been learned about how HIV-induced immune dysfunction contributes to B cell hyperactivation, and potentially, to the pathogenesis of AIDS-lymphoma. However, further studies are needed to fully understand how HIV infection and immune dysfunction promote B cell hyperactivation and the development/growth of AIDS-lymphoma. In particular, studies are needed to define the role of HHV8 vIL6, IL6 receptor-expression, and lymphocyte surface stimulatory molecules, in promoting B cell hyperactivation or lymphoma cell growth.
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