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Cytokines in the modulation of eosinophilia
L H Faccioli1, B B Vargaftig, A I Medeiros
1Departamento de Parasitologia, Microbiologia e Imunologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brasil. faccioli@fmrp.usp.br
Memorias Do Instituto Oswaldo Cruz
|January 1, 1997
Abstract:
In this review we discuss our recently results showing interleukin 5 (IL-5) involvement in eosinophil migration and in the maintenance of eosinophilia in blood, bone marrow, lung and peritoneal cavity, in a visceral larva migrans syndrome model using guinea-pigs infected with Toxocara canis. We also describe the sequential release of TNF-alpha and IL-8 during the course of infection. Finally we propose a biological role for IL-5, at least in our model, as a modulator of IL-8 release and secretion.