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Modulation by IL-10 of antigen-induced allergic responses in mice
C Zuany-Amorim1, B B Vargaftig, M Pretolani
1Unité de Pharmacologie Cellulaire, Institut Pasteur, INSERM n degrees 485, Paris, France.
Abstract:
Over the last few years, we examined the anti-allergic properties of interleukin (IL)-10 in different models of inflammation in the mouse, as well as against IgE-dependent activation of mouse bone marrow-derived mast cells (BMMC). We showed that IL-10, concurrently administered with ovalbumin, inhibited inflammatory cell accumulation in the airways and in the peritoneal cavity of sensitized mice, as well as the accompanying cytokine release. IL-10 also blocked antigen-induced cytokine generation by IgE-stimulated BMMC. Together, these results identify a novel biological property of IL-10, as a cytokine with potent anti-allergic activities.