Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hippocampal plasticity involves extensive gene induction and multiple cellular mechanisms

D Hevroni1, A Rattner, M Bundman

  • 1Department of Hormone Research, Weizmann Institute of Science, Rehovot, Israel.

Journal of Molecular Neuroscience : MN
|August 12, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Axonal Transport of Lysosomes Is Unaffected in Glucocerebrosidase-Inhibited iPSC-Derived Forebrain Neurons.

eNeuro·2023
Same author

GSK3β Impairs KIF1A Transport in a Cellular Model of Alzheimer's Disease but Does Not Regulate Motor Motility at S402.

eNeuro·2020
Same author

The role of the GABAA receptor Alpha 1 subunit in the ventral hippocampus in stress resilience.

Scientific reports·2019
Same author

Corrigendum to differential roles of PKC isoforms (PKCs) and Ca<sup>2+</sup> in GnRH and phorbol 12-myristate 13-acetate (PMA) stimulation of p38MAPK phosphorylation in immortalized gonadotrope cells. [Mol Cell Endocrinol 439: 141-154 (2017)].

Molecular and cellular endocrinology·2019
Same author

Mortality following surgery for trauma in an Indian trauma cohort.

The British journal of surgery·2018
Same author

Pre-trauma Methylphenidate in rats reduces PTSD-like reactions one month later.

Translational psychiatry·2017
Same journal

Postoperative Impairment of GluA2 Ttrafficking in CA3 Induces Memory Consolidation Deficits in Aged Mice by Disrupting SPW-R in CA1.

Journal of molecular neuroscience : MN·2026
Same journal

MYH2 as a Potential Modifier of Clinical Severity in Facioscapulohumeral Muscular Dystrophy.

Journal of molecular neuroscience : MN·2026
Same journal

Notch Signaling Regulates the Neuroprotective Effects of hUCMSCs in a Mouse Model of Cerebral Ischemia.

Journal of molecular neuroscience : MN·2026
Same journal

Co-Administration of LPC and LPS Enhanced the Spinal Cord Vulnerability in a Mouse Model of Focal Demyelination.

Journal of molecular neuroscience : MN·2026
Same journal

Biomarker Based ARIA Stress Test: A Proposed Conceptual Framework for Dynamic Biomarker-Guided ARIA Risk Stratification in Anti-Amyloid Immunotherapy for Alzheimer's Disease.

Journal of molecular neuroscience : MN·2026
Same journal

The Association Between Alzheimer's Disease-Related Biomarkers And Parkinson's Disease Based On Single-Cell Sequencing Analysis Combined With Mendelian Randomization.

Journal of molecular neuroscience : MN·2026
See all related articles

Researchers identified hundreds of candidate plasticity-related genes (CPGs) in the brain using kainate. Many of these genes are involved in neural plasticity and are also upregulated by long-term potentiation (LTP).

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Long-term plasticity in the central nervous system (CNS) involves gene induction, but the specific genes are not fully understood.
  • Understanding these genes is crucial for deciphering the molecular mechanisms of learning and memory.

Purpose of the Study:

  • To identify candidate plasticity-related genes (CPGs) regulated by glutamate receptor activation in the hippocampus.
  • To investigate the role of these CPGs in neural plasticity, specifically long-term potentiation (LTP).

Main Methods:

  • Conducted a comprehensive gene screen in the hippocampus dentate gyrus (DG) after kainate treatment to identify upregulated and downregulated transcripts.
  • Validated the function of novel CPGs in vitro and assessed the induction of known CPGs by LTP-inducing stimuli.

Related Experiment Videos

Main Results:

  • Identified 362 upregulated CPGs and 41 downregulated transcripts (dCPGs).
  • Discovered seven novel CPGs with predicted functions, including cytoskeletal proteins, heat-shock proteins, protein kinases, transcription factors, phosphatases, and receptors.
  • Confirmed that approximately 25% of the tested CPGs are upregulated by LTP, indicating a significant overlap in gene expression responses.

Conclusions:

  • Glutamate receptor activation induces a broad genetic response in the mammalian brain.
  • A substantial portion of these induced genes are also co-activated by long-term potentiation (LTP).
  • These findings suggest diverse cellular mechanisms contribute to long-term neural plasticity.