Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Teratogen update: congenital rubella

W S Webster1

  • 1Department of Anatomy and Histology, University of Sydney, Australia.

Teratology
|August 12, 1998
PubMed
Summary
This summary is machine-generated.

Congenital rubella syndrome (CRS) pathogenesis remains unclear, particularly regarding early embryonic viral spread and late manifestations. Fetal immune responses and maternal IgG may limit early damage, but the virus persists.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antipsychotic drugs cause bradycardia in GD 13 rat embryos in vitro.

Reproductive toxicology (Elmsford, N.Y.)·2012
Same author

Effects of a desealant formulation, SR-51(®) and its individual components on the oxidative functions of mitochondria.

Environmental toxicology and pharmacology·2011
Same author

Improved methodology for identifying the teratogenic potential in early drug development of hERG channel blocking drugs.

Reproductive toxicology (Elmsford, N.Y.)·2010
Same author

Genotoxicity studies of a desealant solvent mixture, SR-51.

Toxicology and industrial health·2009
Same author

The growth of the nasal septum in the 6-9 week period of foetal development--Warfarin embryopathy offers a new insight into prenatal facial development.

Australian dental journal·2005
Same author

Testicular changes induced by chronic exposure to the herbicide formulation, Tordon 75D (2,4-dichlorophenoxyacetic acid and picloram) in rats.

Reproductive toxicology (Elmsford, N.Y.)·2002

Area of Science:

  • Virology
  • Immunology
  • Developmental Biology

Background:

  • Congenital rubella syndrome (CRS) pathogenesis presents numerous unanswered questions, especially concerning viral spread and host response during gestation.
  • Early embryonic infection with rubella virus does not elicit a conventional immune response, yet viral cell infection rates are low, suggesting unknown regulatory mechanisms.

Observation:

  • Rubella virus appears to spread via the fetal vascular system, causing cytopathic damage to blood vessels and the heart lining.
  • This vascular damage is implicated in cardiovascular, central nervous system (CNS), hearing defects, and generalized growth retardation.
  • Ocular effects, like cataracts, result from direct cytopathic damage to the lens, with susceptibility limited by the lens capsule.

Findings:

  • Susceptibility to major defects (deafness, cardiovascular, neurological, retinopathy) is highest in the first 16 weeks of gestation.

Related Experiment Videos

  • Decreased susceptibility after 16 weeks correlates with the development of fetal immune responses and maternal immunoglobulin G (IgG) transfer.
  • While antibody production may limit vascular damage, established intracellular virus is not cleared, and the causes of late-manifesting symptoms are unknown.

    • Implications:

    • Understanding early viral control mechanisms is crucial for preventing CRS.
    • The persistence of intracellular virus suggests potential for late-onset complications, mirroring effects of other teratogens.
    • These findings highlight the need for careful consideration in animal reproductive toxicology testing for potential late-emerging effects.