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Hypothermia increases the threshold for ischemic preconditioning

K Dote1, R A Wolff, D M Van Winkle

  • 1Department of Anesthesiology, Ehime University, Japan.

The Journal of Thoracic and Cardiovascular Surgery
|August 12, 1998
PubMed
Summary
This summary is machine-generated.

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Hypothermia during ischemic preconditioning increases the number of preconditioning cycles needed to protect the heart from ischemia and reperfusion injury. More cycles are required under hypothermia to achieve infarct limitation.

Area of Science:

  • Cardiovascular Physiology
  • Myocardial Ischemia and Reperfusion Injury

Background:

  • Ischemic preconditioning (IP) and hypothermia are known cardioprotective strategies against ischemia-reperfusion (I/R) injury.
  • The combined effects of hypothermia during IP on myocardial tolerance to I/R injury are not fully understood.

Purpose of the Study:

  • To investigate whether hypothermia during the ischemic preconditioning period attenuates the protective effect of IP against myocardial I/R injury.

Main Methods:

  • Isolated rabbit hearts underwent 45 minutes of regional ischemia and 2 hours of reperfusion.
  • Ischemic preconditioning was induced using one or four cycles of 5-minute ischemia.
  • Hypothermia (25°C) was applied during the preconditioning period, with normothermia (38°C) restored before the main ischemic insult.

Related Experiment Videos

Main Results:

  • Normothermic IP significantly reduced infarct size (58% with one cycle, 95% with four cycles).
  • Hypothermic IP with one cycle showed no infarct size reduction, while four cycles reduced infarct size by 94%.
  • Myocardial glycogen and lactate levels were preserved during hypothermic ischemia.

Conclusions:

  • Hypothermia during the preconditioning period increases the threshold for eliciting the infarct-limiting effect of ischemic preconditioning.
  • Multiple cycles of ischemia are necessary to achieve cardioprotection when hypothermia is applied during the preconditioning phase.