Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structural considerations. Early intervention in childhood asthma

P H Burri1, A A Hislop

  • 1Institute of Anatomy, University of Berne, Switzerland.

The European Respiratory Journal. Supplement
|August 12, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A simple tool for stereological assessment of digital images: the STEPanizer.

Journal of microscopy·2011
Same author

Long-term efficacy of bosentan in treatment of pulmonary arterial hypertension in children.

The European respiratory journal·2010
Same author

Childhood idiopathic pulmonary arterial hypertension: a national cohort study.

Heart (British Cardiac Society)·2010
Same author

Prenatal diagnosis of primary pulmonary hypoplasia in fraternal twins.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2009
Same author

Treatment and survival in children with pulmonary arterial hypertension: the UK Pulmonary Hypertension Service for Children 2001-2006.

Heart (British Cardiac Society)·2008
Same author

The 6-minute walk test: normal values for children of 4-11 years of age.

Archives of disease in childhood·2007
Same journal

Current status of lung transplantation.

The European respiratory journal. Supplement·2003
Same journal

Treatment of chronic respiratory failure: lung volume reduction surgery versus rehabilitation.

The European respiratory journal. Supplement·2003
Same journal

Home ventilation.

The European respiratory journal. Supplement·2003
Same journal

Mechanical ventilation: invasive versus noninvasive.

The European respiratory journal. Supplement·2003
Same journal

Respiratory failure in chronic obstructive pulmonary disease.

The European respiratory journal. Supplement·2003
Same journal

Physical and biological triggers of ventilator-induced lung injury and its prevention.

The European respiratory journal. Supplement·2003
See all related articles

Therapeutic treatments during development can harm critical organ growth. Perinatal drug exposure, like glucocorticoids, can inhibit lung alveolar development, necessitating cautious drug use in infants.

Area of Science:

  • Developmental Biology
  • Pharmacology
  • Neonatal Medicine

Background:

  • Therapeutic interventions in developing organisms risk interfering with critical organogenesis.
  • Drug dosage and timing are crucial due to potential adverse effects on growth and development.
  • Perinatal factors significantly impact lung development, specifically alveolarization and microvascular maturation.

Purpose of the Study:

  • To review the impact of perinatal factors on lung development.
  • To analyze the mechanism by which glucocorticoids inhibit alveolization.
  • To emphasize the need for caution when administering potent drugs to developing organisms.

Main Methods:

  • Review of existing literature on lung development and perinatal influences.
  • Analysis of animal experimental data on glucocorticoid effects.

Related Experiment Videos

  • Hypothesis generation for the mechanism of glucocorticoid-induced inhibition of alveolization.

    • Main Results:

    • Perinatal exposure to various factors, including drugs like glucocorticoids, can disrupt lung development.
    • Even low doses of perinatal glucocorticoids were shown to inhibit alveolization in animal models.
    • The precise effects on human infants are challenging to assess noninvasively.

    Conclusions:

    • Perinatal drug administration requires careful consideration due to potential long-term consequences on lung structure.
    • Glucocorticoids are identified as a significant factor that can impair lung alveolar development.
    • Strong recommendations are made for the cautious use of potent medications in perinatal and infant care.