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Structural considerations. Early intervention in childhood asthma

P H Burri1, A A Hislop

  • 1Institute of Anatomy, University of Berne, Switzerland.

The European Respiratory Journal. Supplement
|August 12, 1998
PubMed

Insights

Therapeutic treatments during development can harm critical organ growth. Perinatal drug exposure, like glucocorticoids, can inhibit lung alveolar development, necessitating cautious drug use in infants.

Area of Science:

  • Developmental Biology
  • Pharmacology
  • Neonatal Medicine

Background:

  • Therapeutic interventions in developing organisms risk interfering with critical organogenesis.
  • Drug dosage and timing are crucial due to potential adverse effects on growth and development.
  • Perinatal factors significantly impact lung development, specifically alveolarization and microvascular maturation.

Purpose of the Study:

  • To review the impact of perinatal factors on lung development.
  • To analyze the mechanism by which glucocorticoids inhibit alveolization.
  • To emphasize the need for caution when administering potent drugs to developing organisms.

Main Methods:

  • Review of existing literature on lung development and perinatal influences.
  • Analysis of animal experimental data on glucocorticoid effects.
  • Hypothesis generation for the mechanism of glucocorticoid-induced inhibition of alveolization.

Main Results:

  • Perinatal exposure to various factors, including drugs like glucocorticoids, can disrupt lung development.
  • Even low doses of perinatal glucocorticoids were shown to inhibit alveolization in animal models.
  • The precise effects on human infants are challenging to assess noninvasively.

Conclusions:

  • Perinatal drug administration requires careful consideration due to potential long-term consequences on lung structure.
  • Glucocorticoids are identified as a significant factor that can impair lung alveolar development.
  • Strong recommendations are made for the cautious use of potent medications in perinatal and infant care.

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