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The pathophysiological role of estrogen receptor variants in human breast cancer
L C Murphy1, H Dotzlaw, E Leygue
1Department of Biochemistry and Molecular Biology, University of Manitoba, Winnipeg, Canada. lcmurph@cc.umanitoba.ca
The Journal of Steroid Biochemistry and Molecular Biology
|August 12, 1998
Abstract:
The accumulated evidence supports the expression of estrogen receptor variants at both the mRNA and protein levels. The relative level of expression of some estrogen receptor variant mRNAs and possibly progesterone receptor variant mRNAs is altered during breast tumorigenesis and breast cancer progression. The altered expression of estrogen receptor variants may effect estrogen signal transduction as well as the interpretation of assays where the estimation of estrogen receptor levels is used as a guide to treatment strategies and prognosis.