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Related Experiment Videos

Interactions between fenoprofen sodium and poly (ethylene oxide)

T Rades1, C C Mueller-Goymann

  • 1University of Otago, Dunedin, New Zealand.

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V
|August 12, 1998
PubMed
Summary

Fenoprofen sodium (FNa) interacts with poly (ethylene oxide) (PEO) at a molecular level, influencing its liquid crystalline formulations. These interactions, independent of PEO chain length, alter drug solubility and mesophase behavior.

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Area of Science:

  • Physical Chemistry
  • Materials Science
  • Pharmaceutical Sciences

Background:

  • Amphiphilic drugs like fenoprofen sodium (FNa) can form complex interactions in solution.
  • Poly (ethylene oxide) (PEO) is a polymer with potential applications in drug delivery systems.
  • Understanding drug-polymer interactions is crucial for developing stable and effective pharmaceutical formulations.

Purpose of the Study:

  • To investigate the interactions between fenoprofen sodium (FNa) and poly (ethylene oxide) (PEO).
  • To explore the impact of these interactions on fenoprofen liquid crystalline (FLC) formulations.
  • To elucidate the mechanism and consequences of FNa-PEO interactions on drug solubility and phase behavior.

Main Methods:

  • Surface tension measurements

Related Experiment Videos

  • Viscometry
  • Cloud point temperature measurements
  • [1H]NMR spectroscopy
  • Polarised light microscopy
  • Transmission electron microscopy
  • Differential scanning calorimetry

    • Main Results:

    • Interactions between FNa and PEO were observed even below FNa's critical micelle concentration (CMC).
    • PEO addition led to partial or complete dissolution of the FLC mesophase, forming an isotropic phase.
    • These interactions were independent of PEO chain length and occurred at a molecular level, not micellar.

    Conclusions:

    • Fenoprofen sodium interacts with poly (ethylene oxide) via hydrophobic interactions at the molecular level.
    • PEO addition alters the phase behavior of fenoprofen liquid crystalline formulations, promoting dissolution and increasing transition temperatures.
    • The findings suggest potential for PEO in modifying the properties of fenoprofen-based drug delivery systems.