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Atypical cells in radiation dermatitis express factor XIIIa
J C Moretto1, R A Soslow, B R Smoller
1Department of Pathology, Stanford University Medical Center, California, USA.
The American Journal of Dermatopathology
|August 13, 1998
Summary
Atypical cells in radiation dermatitis are primarily dermal dendritic cells expressing factor XIIIa. This finding helps understand skin changes after radiation therapy.
Area of Science:
- Dermatology
- Immunohistochemistry
- Cell Biology
Background:
- Dendritic cells expressing factor XIIIa are normally found in the dermis.
- These cells increase in various pathological conditions.
- Atypical dermal cells are frequently observed in skin biopsy specimens following radiation exposure.
Purpose of the Study:
- To investigate whether atypical dermal cells in chronic radiation dermatitis express factor XIIIa.
- To differentiate the origin of atypical dermal cells in radiation dermatitis.
Main Methods:
- Standard immunohistochemical techniques were used.
- Antibodies for factor XIIIa and CD34 were employed.
- Sixteen biopsy samples of radiation dermatitis were analyzed.
Main Results:
- All 16 cases demonstrated diffuse positive cytoplasmic staining for factor XIIIa in atypical dermal cells.
- Ten out of 16 cases showed focal staining with the CD34 antibody.
- The CD34 antibody did not react with the majority of atypical dermal cells.
Conclusions:
- The majority of atypical dermal cells observed in radiation dermatitis originate from dermal dendritic cells.
- These cells are characterized by their expression of factor XIIIa.