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Updated: Jul 26, 2026

Understanding Early Organogenesis Using a Simplified In Situ Hybridization Protocol in Xenopus
Published on: January 12, 2015
Induction and early development of the hematopoietic and immune systems in Xenopus
1Department of Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha 68198-6395, USA. jturpen@unmc.edu
Abstract:
This paper reviews several aspects of the development of the hematopoietic and lymphoid systems in Xenopus. The developmental biology of hematopoietic stem cells and the early development of the thymus and B-cells are discussed. Recent advances in the development of molecular indices of the hematopoietic program are also considered. Previous studies as well as new data demonstrate that the hematopoietic program is initiated at the time of gastrulation. Recent advances suggest that both positive and negative regulation is necessary for the appropriate spatial and temporal expression of the hematopoietic program during development.
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