Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intercellular calcium waves in glia

A Charles1

  • 1Department of Neurology, UCLA School of Medicine, Los Angeles, California, USA. acharles@ucla.edu

Glia
|August 13, 1998
PubMed
Summary
This summary is machine-generated.

Glial cells communicate via intercellular calcium (Ca2+) waves, using both gap junctions and extracellular messengers. A rapid signal may precede these waves, enabling swift glial-neuronal communication.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Renal Masses in Childhood: An Australian Perspective.

Journal of paediatrics and child health·2025
Same author

Generalized sarcoidosis associated with hypertrophic osteopathy in a Standardbred racehorse.

Journal of equine veterinary science·2024
Same author

Selection for treatment of patients at high risk of fracture by the short versus long term prediction models - data from the Belgian FRISBEE cohort.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2023
Same author

The effect of fracture recency on observed 5-year fracture probability: A study based on the FRISBEE cohort.

Bone reports·2023
Same author

[Physical activity in nursing homes: contributions of the SENIOR cohort].

Revue medicale de Liege·2023
Same author

Are there specific clinical risk factors for the occurrence of multiple fractures? The FRISBEE study.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2023
Same journal

A Super-Resolution Approach for Astrocyte-Specific Molecular Imaging Reveals the Nanoscale Distribution of Monoacylglycerol Lipase, the Metabolic Node Between Endocannabinoid and Prostaglandin Signaling.

Glia·2026
Same journal

Blocking CK2α-Bclaf1 Preserves Oligodendrocytes After Neonatal Hypoxic Injury.

Glia·2026
Same journal

Molecular Characteristics and Differentiation Control Mechanisms of Bergmann Glia-Like Progenitors in the Postnatal Mouse Cerebellum.

Glia·2026
Same journal

Alzheimer's Protection by PLCγ2 Compacts Plaques, Redistributes Microglia, and Protects Synapses in App<sup>NL</sup> <sup>-G-F</sup> Mice.

Glia·2026
Same journal

Single-Nucleus Multiomic Analysis Reveals Immune-Metabolic Reprogramming Consistent With Maladaptive Trained Immunity in HIV-Associated Neurocognitive Disorders.

Glia·2026
Same journal

Plasma Membrane Remodeling During Microglial Activation: A Hypothesis Linking Microglial Shape and Lipid Droplet Formation.

Glia·2026
See all related articles

Area of Science:

  • Neuroscience
  • Cell Biology
  • Glial Cell Signaling

Background:

  • Glial cells exhibit intercellular calcium (Ca2+) waves, a widespread signaling phenomenon.
  • These waves are observed across various preparations, including cultures, slices, and intact retinas.
  • Ca2+ wave characteristics vary, suggesting diverse signaling pathways.

Purpose of the Study:

  • To investigate the mechanisms of mechanically induced glial Ca2+ waves.
  • To explore the role of gap junctions and extracellular messengers in glial signaling.
  • To examine rapid glial-neuronal communication preceding Ca2+ waves.

Main Methods:

  • Experimental induction of Ca2+ waves in glial cells.
  • Pharmacological analysis of signaling pathways.

Related Experiment Videos

  • Observation of Ca2+ wave initiation and propagation patterns.
  • Investigation of rapid signaling preceding glial Ca2+ waves.

    • Main Results:

    • Mechanically induced glial Ca2+ waves involve both gap junction and extracellular messenger signaling.
    • Evidence suggests a rapidly propagated signal precedes the glial Ca2+ wave.
    • This preceding signal may mediate rapid glial-neuronal communication.

    Conclusions:

    • Glial intercellular Ca2+ waves utilize a combination of signaling mechanisms.
    • A novel, rapid signaling event may link glial activity to neuronal communication.
    • Understanding these pathways is crucial for comprehending glial cell function in health and disease.