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Altered membrane permeability as the basis of bactericidal action of methdilazine
D Chattopadhyay1, T Mukherjee, P Pal
1Department of Cellular Biochemistry, Indian Institute of Chemical Biology, Calcutta, India.
The Journal of Antimicrobial Chemotherapy
|August 13, 1998
Abstract:
The growth inhibition of Escherichia coli and Staphylococcus aureus was accompanied by significant release of K+ and UV-absorbing small molecules upon exposure to methdilazine, an extensively used phenothiazine antihistamine. A severe decrease in [U-14C] glucose uptake and a rapid efflux of hexose from sugar-preloaded bacteria were also observed but without visible cellular lysis. Considerable damage to membrane permeability by methdilazine was proposed to explain the rapid loss in cfu/mL of the bacteria.