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[Angiotensin-induced hypertension in pigs]
Acta Biologica Et Medica Germanica
|January 1, 1976
Summary
Pigs exhibit significant blood pressure increases after depot angiotensin injections, demonstrating higher sensitivity than rats. This study establishes pigs as a valuable model for hypertension research.
Area of Science:
- Cardiovascular Physiology
- Animal Models in Research
Context:
- Investigating the physiological effects of angiotensin in vivo.
- Evaluating the suitability of pigs as an experimental model for hypertension studies.
Purpose:
- To assess the impact of repeated depot angiotensin administration on blood pressure in pigs.
- To compare the hypertensive response and pathological changes in pigs versus rats.
Summary:
- Daily depot angiotensin injections in pigs caused substantial, sustained increases in systolic and diastolic blood pressure, with pigs showing greater sensitivity than rats.
- While angiotensin induced vasoconstriction, significant light-microscopic alterations in vessels, kidneys, or myocardium were not observed, though some arterioles showed wall thickening.
Impact:
- Identifies pigs as a suitable animal model for comparative hypertension research.
- Highlights the utility of unbloody caudal artery blood pressure measurements in pigs during prolonged experiments.