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Motilin increases food intake in mice
1Second Department of Internal Medicine, Kobe University School of Medicine, Japan.
Peptides
|August 13, 1998
Summary
Motilin administration significantly increased food intake in mice, an effect blocked by a specific motilin receptor antagonist. This suggests brain motilin receptors play a role in regulating appetite.
Area of Science:
- Neuroscience
- Endocrinology
- Gastroenterology
Background:
- Motilin is a gastrointestinal hormone primarily known for regulating gastric motility.
- Its potential role in central appetite regulation remains less understood.
- Investigating the central effects of motilin could reveal novel pathways in food intake control.
Purpose of the Study:
- To investigate the effect of central motilin administration on food intake in mice.
- To determine if motilin's effects on feeding are mediated through specific brain receptors.
Main Methods:
- Intracerebroventricular (ICV) administration of motilin in nonfood-deprived mice.
- Administration of a selective motilin receptor antagonist (GM-109) to assess blockade of motilin's effects.
- Dose-response analysis of the antagonist's efficacy.
- Monitoring of food intake over time.
Main Results:
- ICV motilin administration (3 nmol/mouse) significantly increased food intake starting at 1 hour and lasting for 2 hours.
- The motilin receptor antagonist GM-109 dose-dependently attenuated this increase in food intake.
- GM-109 alone did not affect food intake, confirming its specificity.
Conclusions:
- These findings indicate the presence and functional relevance of motilin receptors within the brain.
- Central motilin signaling appears to stimulate food intake.
- Motilin may represent a novel target for modulating appetite and energy balance.